2004.9-2008.6   华中农业大学  本科

2008.9-2014.7   中国科学院大学（上海植物生理生态研究所）  博士

2014.11-2015.9  罗格斯大学罗伯特伍德强生医学院公共卫生研究所 博士后

2015.10-2019.5  约翰斯霍普金斯大学布隆伯格公共卫生学院疟原虫研究所  博士后

2019.5-2023.10  约翰斯霍普金斯大学布隆伯格公共卫生学院疟原虫研究所 助理研究员

2023.11-        中国科学院上海免疫与感染研究所 研究员

1. Huang W., Rodrigues J*., Tormo J., Bilgo E., Challenger J., Cozar-Gallardo C., Pérez-Victoria I., Reyes F., Gnambani E., Hien D., Konkobo M., Ruano M., Casta？eda -Casado P., Coppens I., Mendoza-Losana A., Ballell L., Diabate A., Churcher T., Jacbos-Lorena M*. (2023). Delftia tsuruhatensis TC1 symbiont suppresses malaria transmission by anopheline mosquitoes. Science.

2. Huang W., Vega-Rodriguez J., Kizito C., Jacbos-Lorena M. (2022). Combining transgenesis with paratransgenesis to fight malaria. Elife. 

3. Huang, W*., Fu, K., Gao, Q., Tejo, R. P., Floeter-Winter, L. M., & Gutierrez, A. P. (Eds.). (2022). Host-microbe interaction and coevolution. Frontiers Media SA (Editorial for Frontiers in Microbiology and Frontiers in Genetics).

4. Huang W, Cha S J, Jacobs‐Lorena M. New weapons to fight malaria transmission: A historical view. Entomological Research, 2022.

5. Huang W., Wang S., Jacbos-Lorena M. (2020). Self-limiting Paratransgenesis. PLOS Neglected Tropical Diseases.

6. Huang, W., Wang, S., & Jacobs-Lorena, M. (2020). Use of Microbiota to Fight Mosquito-Borne Disease. Frontiers in Genetics, 11.

7. Huang, W., Hong, S., Tang, G., Lu, Y., & Wang, C. (2019). Unveiling the function and regulation control of the DUF3129 family proteins in fungal infection of hosts. Philosophical Transactions of the Royal Society B, 374(1767), 20180321.

8. Huang, W., Liao, G., Baker, G. M., Wang, Y., Lau, R., Paderu, P., ... & Xue, C. (2016). Lipid Flippase Subunit Cdc50 Mediates Drug Resistance and Virulence in Cryptococcus neoformans. mBio, 7(3), e00478-16.

9. Huang W., Shang Y. F., Chen P. L., Cen K., & Wang, C. S. (2015). Basic leucine zipper (bZIP) domain transcription factor MBZ1 regulates cell wall integrity, spore adherence, and virulence in Metarhizium robertsii. Journal of Biological Chemistry, 290(13), 8218-8231.

10. Huang W., Shang Y. F., Chen P. L., Gao Q., Wang C. S. (2015). MrpacC regulates sporulation, insect cuticle penetration and immune evasion in Metarhizium robertsii. Environmental Microbiology, 17(4), 994-1008. 

11. Huang W., Zhang Y. H., Chen D. Q., Hu H. Q., Zhuang G. Q. (2009). Degradation and Remaining of the Bt Protein in Several Soils. Journal of Huazhong Agricultural University, 28(2): 169-173. (In Chinese)

12. Godoy, R. S. M., Barbosa, R. C., Huang, W., Secundino, N. F. C., Pimenta, P. F. P., Jacobs-Lorena, M., & Martins, G. F. (2023). The larval midgut of Anopheles, Aedes, and Toxorhynchites mosquitoes (Diptera, Culicidae): a comparative approach in morphophysiology and evolution. Cell and Tissue Research, 1-24.

13. Pascini, T. V., Jeong, Y. J., Huang, W., Pala, Z. R., Sá, J. M., Wells, M. B., ... & Vega-Rodríguez, J. (2022). Transgenic Anopheles mosquitoes expressing human PAI-1 impair malaria transmission. Nature communications, 13(1), 1-16.

14. Gao, H., Bai, L., Jiang, Y., Huang, W., Wang, L., Li, S., ... & Wang, S. (2021). A natural symbiotic bacterium drives mosquito refractoriness to Plasmodium infection via secretion of an antimalarial lipase. Nature Microbiology, 1-12.

15. Wang, S., Dos-Santos, A. L., Huang, W., Liu, K. C., Oshaghi, M. A., Wei, G., ... & Jacobs-Lorena, M. (2017). Driving mosquito refractoriness to Plasmodium falciparum with engineered symbiotic bacteria. Science, 357(6358), 1399-1402.

16. Gao, Q., Lu, Y., Yao, H., Xu, Y. J., Huang, W., & Wang, C. S. (2016). Phospholipid homeostasis maintains cell polarity, development and virulence in Metarhizium robertsii. Environmental Microbiology, 18(11), 3976-3990.

17. Duan Z.B., Chen Y. X., Huang W., Shang Y. F., Chen P. L., Wang C. S. (2013). Linkage of autophagy to fungal development, lipid storage and virulence in Metarhizium robertsii. Autophagy, 9(4), 538-549.

18. Gao Q*., Shang Y. F*., Huang W., Wang C. S. (2013). Glycerol-3-phosphate acyltransferase contributes to triacylglycerol biosynthesis, lipid droplet formation and host invasion in Metarhizium robertsii. Applied and Environmental Microbiology, 79, 7646-7653.

19. Shang Y. F., Duan Z. B., Huang W., Gao Q., Wang C. S. (2012). Improving UV resistance and virulence of Beauveria bassiana by genetic engineering with an exogenous tyrosinase gene. Journal of Invertebrate Pathology, 109(1), 105-109.

20. Gao Q., Jin K., Ying S. H., Zhang Y. J., Xiao G. H., Shang Y. F., Duan Z. B., Hu X., Xie X. Q., Zhou G., Peng G. X., Luo Z. B., Huang W., Wang B., Fang W. G., Wang S. B., Zhong Y., Ma L.J., St. Leger R. J., Zhao G. P., Pei Y., Feng M. G., Xia Y. X. and Wang C. S. (2011). Genome sequencing and comparative transcriptomics of the model entomopathogenic fungi Metarhizium anisopliae and M. acridum. PLoS Genetics, 7(1), e1001264.

21. Fu, Q. L., Zhang, Y. H., Huang, W., Hu, H. Q., Chen, D. Q., & Yang, C. (2012). Remaining dynamics of Cry1Ab proteins from transgenic Bt corn in soil. Journal of Food, Agriculture & Environment, 10(1), 294-298.

22. Zhang Y. H., Huang W., Hu H. Q., Liu Y. R., Chen D. Q. (2007). Remaining Dynamics of Cry1Ab Proteins from Transgenic Bt Corn in Soils. Journal of Huazhong Agricultural University, 26(2), 485-490. (In Chinese)

1. 发现和鉴定蚊虫共生细菌（代尔夫特菌和沙雷氏菌），并利用其阻断疟原虫的蚊期传播（2017, Science; 2020, PLoS neglected tropical diseases; 2021, Nature Microbiology; 2023, Science）

2.转基因蚊虫和共生细菌协同阻断疟原虫的蚊期传播（eLife, 2022）

3. 系统性研究杀虫（包括蚊虫）真菌的罗伯茨绿僵菌转录因子调控真菌杀虫毒力和生长发育（2015, Environmental Microbiology; 2015, Journal of Biological Chemistry; 2019, Philosophical Transactions of the Royal Society B）

4. 首次发现人类致病真菌新型隐球菌耐新型广谱抗生素卡帕芬净的耐药机制，找到关键的耐药靶标膜蛋白，对于今后开发克服耐卡帕芬净耐药的辅助方法提供靶标和新思路（2017, mBio）

蚊媒传染病，是由病媒蚊子叮咬传播的自然疫源性疾病，常见的有流行性乙型脑炎、疟疾、登革热、基孔肯雅热、丝虫病、黄热病等危害性较强的传染病。蚊媒传染病每年导致70余万人死亡，全球一半以上的人口被蚊媒传染病威胁。因此阻断蚊媒传染病的传播迫在眉睫，而阻断病原体的蚊媒阶段传播是关键。

研究组围绕蚊虫研究为中心，研究蚊虫、蚊媒病原体（疟原虫或者虫媒病毒）、蚊虫共生细菌以及人之间的相互作用关系，基于此发展阻断蚊媒传染病的策略，开发预防和治疗蚊媒传染病的疫苗和药物。

研究组结合生物化学以及分子生物学等手段研究以下几方面内容：

1.研究包括共生细菌和转基因蚊虫在内的蚊媒传染病的阻断策略；

2.研究蚊媒病原对于蚊虫、哺乳动物等宿主的侵染和宿主的防御机制；

3.研究针对蚊媒病原的高效疫苗和治疗药物；

4.研究控制蚊虫种群数量的生物防治策略。

实验室成员（Lab member)

招生信息（admission information)

欢迎具有生物学和化学背景的优秀学生加入本团队攻读硕士和博士研究生。

欢迎大学二年级（含）以上同学进入实验室参与有关科研学术工作，或联系毕业设计等。